Trajectories of marijuana use among hivseropositive and hivseronegative msm in the multicenter aids cohort study macs, 1984 20 3 june 2016 aids and behavior, vol. He is the charles armstrong chair of the department of epidemiology at the johns hopkins bloomberg school of public health. Mortality among participants in the multicenter aids cohort study. A prospective study of 558 hivinfected men enrolled in the multicenter aids cohort study between 19902010.
We tested a theory of syndemic production among men who have sex with men msm using data from a large cohort study. Medicinal and recreational marijuana use by patients. Selected participants currently being followed include. Mixed membership trajectory models of cognitive impairment. Started in 1984, the study involves collection of biological specimens and medical and behavioral data on msm men who have sex with men in order to study the natural and treated history of hiv. Hiv positive men who were enrolled in the study as seroprevalent cases or who have seroconverted while in the study. Niaids multicenter aids cohort study macs was a collaboration with the aids research center in order to assess cam utilization and health outcomes associated with alternative medicine use among hivpositive macs participants. Adversity and syndemic production among men participating. Lawrence a kingsley, drph graduate school of public health. Pediatric hivaids cohort study phacs multicenter 22. Nih funding opportunities and notices in the nih guide for grants and contracts. The macs study would not be possible without the tremendous commitment of its participants.
Multicenter aids cohort study macs definition aidsinfo. Initial enrollment was in 1984 1985 and subsequent enrollments took place in 19871991, 20012003, and from 2010 onwards. Macs is a study of hiv infection in homosexual and bisexual men. Hiv clinical cohort catalogue harvard university center.
The multicenter aids cohort study, 1983 to sciencedirect. Multicenter aids cohort study macs bastyr university. Mar 26, 1998 for purposes of identification and processing, item 2 on the face page of the application must be marked yes and the rfa number ai98003 and the words multicenter aids cohort study pathogenesis research labs must be entered on the face page. The association of ambient fine particulate matter exposure during pregnancy with blood glucose levels and gestational diabetes mellitus risk. The multicenter aids cohort study macs 1 was initiated in 1983 when four investigators roger detels ucla, john phair northwestern university, frank polk johns hopkins university and charles rinaldo university of pittsburgh, funded by the national institute of allergy and infectious diseases to conduct cohort studies of men who have sex with men, agreed to join forces and. Multicenter aids cohort study multicenter aids cohort study. The multicenter aids cohort study macs is an ongoing cohort study involving over 6,000 men, including both those infected with hiv, as well as hivnegative men. Blood and urine samples we collect are tested with established clinical tests.
The first wave of participant recruitment was completed by march 31, 1985. The multicenter aids cohort study, 1983 to request pdf. In turn, many of these studies have data and specimens available for further investigation. Multicenter aids cohort study multicenter aids cohort. Multicenter aids cohort study macs no study results. Data in this article were collected by the multicenter aids cohort.
May 06, 2009 nih multicenter aids cohort study commemorates 25 years of discovery the longest u. For purposes of identification and processing, item 2 on the face page of the application must be marked yes and the rfa number ai98003 and the words multicenter aids cohort study pathogenesis research labs must be entered on the face page. Macs was a way to put a face to hiva way to build community. The multicenter aids cohort study macs provides important information about the changing nature of hivmediated disease progression, the impact of antiretroviral treatment, the nature of hiv pathogenesis, and viral and host genetic factors. Jul 15, 2009 he wanted to hear about what happened from the mid1980s, when the book ends, through the intervening years. Nonaids defining malignancies in the multicenter aids cohort study macs, 1984 96. Adversity and syndemic production among men participating in. This study will also assess the longterm patterns of therapy use and risktaking behaviors. Okafor cn, barnett w, zar hj, nhapi r, koen n, shoptaw s, stein dj. The multicenter aids cohort study macs was initiated in 1983 when.
Temporal trends in human immunodeficiency virus type 1 seroconversion 1984 1989. Over 5,500 men have participated in the macs since the initial enrollment in 1984. Macs public data set has been released from camacs center for analysis and management of multicenter aids cohort study since 1994 when the macs executive. Researchers internal and external to the macs study can apply to use our data and specimens. Nancy hutton, md faap faahpm johns hopkins hospital.
Conversely, if you have oversee an hiv cohort and have data and specimens that you are. The cause of aids and its risk factors were unknown at the time, but the disease became recognized as new cases developed. The multicenter aids cohort study macs is an ongoing cohort study involving over 6,000. The historical context of aids in america did not provide a clear career pathway for me. Hops is a prospective observational cohort study that was initiated in 1993 by the us centers for disease control and prevention cdc, and is currently expected to continue collecting and analyzing longitudinal data on hivinfected outpatients until mid2011. This page contains submission and approval information, and forms used to collect data. The multicenter aids cohort study was designed to elucidate the natural history of the infection causing acquired immunodeficiency syndrome aids, identify risk factors for occurrence and clinical expression of the infection, and establish a repository of biologic specimens for future study. Epidemiology of hivassociated malignancies springerlink. A total of 5622 men were recruited in 2 fixed cohorts. The multicenter aids cohort study macs has significantly contributed to the understanding of hiv, aids, and the effects of antiretroviral therapy art. The multicenter aids cohort study macs is a 30year study of the hiv1 infection in gay and bisexual men. Biological and behavioral data are collected every six months from study participants. Sep 26, 2002 the multicenter aids cohort study macs provides important information about the changing nature of hivmediated disease progression, the impact of antiretroviral treatment, the nature of hiv pathogenesis, and viral and host genetic factors. Cognitive processing, discovery of meaning, cd4 decline.
Volume 188 issue 11 american journal of epidemiology. Adapted from remarks given on may 12, 2009, at the carnegie institution for science in washington, d. Pediatric hivaids cohort study phacs multicenter 22 sites. Cancer incidence in the multicenter aids cohort study before. A public data tape of the multicenter aids cohort study, covering data from 1984 2010,or visits 153.
The multicenter aida cohort study was conducted in 1984 to determine risky factors of hiv in. Malignancies in the multicenter aids cohort study macs, 1984 1994 abstract. Cancer incidence in the multicenter aids cohort study before and. Upon completion of designing the protocol, recruitment of msm began in april of 1984 into the investigation which was named the multicenter aids cohort study or macs.
Oham hiv aids research programs national cancer institute. Macs public data set has been released from camacs center for analysis and management of multicenter aids cohort study since 1994 when the macs executive committee made the recommendations on the content of the public data. Hiv clinical cohort catalogue harvard university center for. From april 1984 through march 1985 4954 men were enrolled. A report from the multicenter aids cohort study macs. David dupuy celentano born 1951 is a noted epidemiologist and professor who has contributed significantly to the promotion of research on hiv aids and other sexually transmitted infections stis. No hiv seroconversions occurred in 220 homosexual men who did not practise. A total of 1809 hivseropositive homosexual men without the acquired immunodeficiency syndrome aids who entered the multicenter aids cohort study in 1984 or 1985. Between 1984 and 1985,1,637 hivpositive and hivnegative men without aids were enrolled in the macs. If your research can benefit from access to data and specimens from these cohorts, please reach out to the respective study contact. Cancer incidence among hivinfected and hivuninfected participants in the multicenter aids acquired immunodeficiency syndrome cohort study macs between 1984 and 2007 was compared with the expected incidence using us populationbased data from the surveillance, epidemiology epidemiology subject category.
Eightyear followup data were available on 75% of eligible participants. Notice of intent to publish a funding opportunity announcement for field centers, multicenter aids cohort study womens interagency hiv study combined cohort u01 nothl17523. Cancer incidence in the multicenter aids cohort study. Multicenter aids cohort study macs the macs is an ongoing prospective study started in 1984 of the natural and treated histories of hiv1 infection in homosexual and bisexual men conducted at various sites throughout the united states. The multicenter aids cohort study macs is an ongoing prospective cohort study of hivinfected and hivuninfected men who have sex with men in 4 u. Apr 12, 2020 started in 1984, the study involves collection of biological specimens and medical and behavioral data on msm men who have sex with men in order to study the natural and treated history of hiv. When i was told i had hiv, there was no counseling, testing, or referral. One story i told him about the old days concerned a remarkable collection of people both participants and scientists known then and now as the multicenter aids cohort study, or macs. Cancer incidence in the multicenter aids cohort study before and during the haart era. Macswihs combined cohort study national heart, lung. Medicinal and recreational marijuana use by patients infected. The multicenter aids cohort study macs is a foursite longitudinal study of the natural and treated history of hiv disease among gay and.
Incidence of nonaidsdefining cancers nadcs between 1984 and 2014 in the multicenter aids cohort study macs by hiv status and viral infection. The aids work being done at johns hopkins at this time was the groundbreaking multicenter aids cohort study ma s, a longitudinal observational cohort of homosexual men. Their generosity with time and information inspires all of us. Highintensity cannabis use and hiv clinical outcomes among hivpositive people who use. David dupuy celentano born 1951 is a noted epidemiologist and professor who has contributed significantly to the promotion of research on hivaids and other sexually transmitted infections stis. The bastyrmacs collaboration provides an excellent opportunity to measure health outcomes associated with cam use in a cohort from which complete. The hu cfar clinical core connects hivrelated research cohorts with resources. Depressive symptoms as predictors of medical outcomes in. Associations of emotional, physical, or sexual intimate partner violence and depression symptoms among south african women in a prospective cohort study.
The multicenter aids cohort study macs 1 was initiated in 1983 when four investigators roger detels ucla, john phair northwestern university, frank polk johns hopkins university and charles rinaldo university of pittsburgh, funded by the national institute of allergy and infectious diseases to conduct cohort studies of men who have sex with men, agreed to join forces and collaborate to investigate the natural history of acquired immunodeficiency syndrome aids. Trajectories of marijuana use among hivseropositive and hivseronegative msm in the multicenter aids cohort study macs, 1984 20. She has authored over 40 publications in scientific journals and. Multicenter aids cohort study macs public data set nih. Nih multicenter aids cohort study commemorates 25 years of. The multicenter aids cohort study was designed to 1 elucidate the natural history of the infection causing acquired immunodeficiency syndrome aids, 2 identify risk factors for occurrence and clinical expression of the infection, and 3 establish a repository of biologic specimens for future study. Mixed membership trajectory models of cognitive impairment in the multicenter aids cohort study. This chapter presents an overview of hiv outpatient study hops and multicenter aids cohort study macs. Multicenter aids cohort study macs macs started in 1984 and enrolled over 7,000 men who were living with and without hiv at study centers located in baltimore, md. The multicenter aids cohort macs, initiated in 1983 at the johns hopkins school of public health, the university of pittsburgh school of public health, northwestern university school of medicine, and the ucla school of public health, continues to conduct studies and publish key papers on the natural history of untreated and treated hiv infection in 6972 menwhohavesexwithmen.
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